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Protagonist Therapeutics, Inc. (referred to as Protagonist, the Company, we, our or us ) is an integrated discovery and development company with a validated technology platform. Our programs fall into three broad therapeutic areas: (i) inflammation and immunology ( I&I ), (ii) hematology and (iii) metabolic diseases.
$138.77
$2.14 (-1.52%)
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The business is unprofitable at the operating level (-343.63% margin). The thesis depends entirely on whether and when it reaches sustainable profitability.
Revenue declined 89.4% YoY. Margins deteriorated 401.8pp alongside, both lines moving the wrong way.
Free cash flow declined 69% versus the prior year, cash generation momentum has weakened. ROIC dropped from 48.56% to -19.05%, capital efficiency is deteriorating.
Based on TTM earnings · Diluted shares
Profitability & Returns
Revenue (TTM)
$74M
▼ -89.4% YoY
Net Income (TTM)
-$115M
▼ -147.3% YoY
Op. Margin
-192.36%
▼ -401.8pp YoY
ROIC
-17.15%
▼ -67.6pp YoY
Cash Flow & Balance Sheet
FCF (TTM)
-$118M
▼ -69.3% YoY
Op. Cash Flow (TTM)
-$117M
▼ -68.7% YoY
Net Debt
-$538M
Net Cash Position
Cash & Equiv.
$548M
5Y CAGR: +10.0%
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Protagonist Therapeutics (PTGX)'s valuation is best read against its own history, its peers, and the growth its price implies. A high multiple is not the same as overvalued: fast-growing, high-quality businesses can deserve a premium. See the general approach in how to tell if a stock is overvalued.
On quality, Protagonist Therapeutics scores 40/100 on Intrinsiqq's quality scorecard (a mixed business on these measures), weighing growth, margins, returns on capital, share count, and balance-sheet strength. All figures are computed from SEC filings; read the full . This is analysis, not investment advice.
Protagonist Therapeutics scores 40 out of 100 on Intrinsiqq's quality score, a weighted blend of 6 metrics each scored 0 to 100, which makes it a mixed business on these measures. Recent fundamentals include a -192.4% operating margin and a -17.1% return on invested capital. The score weighs revenue and free-cash-flow growth, operating margins, return on invested capital, share-count change, and balance-sheet strength, all computed from SEC filings, not opinion. Because valuation only means something relative to quality, the full metric-by-metric breakdown is on the quality scorecard.
That depends on valuation and quality together, not either alone. you should weigh PTGX's valuation and scores 40/100 on quality (mixed). A cheap price is only a bargain if the business is durable, and a premium can be justified by genuine quality, so the two questions, "is it cheap?" and "is it good?", only make sense side by side. Read the valuation against the quality scorecard, run the DCF on your own assumptions, and decide for yourself. This is analysis from SEC filings, not investment advice.