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State Street SPDR S&P Biotech ETF Holdings

XBIETF · NYSE Arca

$157.77

+$0.26 (+0.17%)

EOD Oct 29, 2026

XBI holds 159 stocks and 10 other positions (cash and equivalents). The largest is Moderna, Inc. at 2.27%, and the ten largest make up 17.8% of assets. Holdings as of Oct 28, 2026.

Quality of what it owns

38

Stock weight by each holding's Quality score

Dividend strength of what it owns

4

Stock weight by each holding's Dividend score: five years of payments, payout ratio, growth

All 159 stocks

Weight as a share of the fund's assets, Oct 28, 2026

XBI holdings by weight
#CompanySector
1Moderna, Inc.MRNAHealthcare2.27%n/a200
2Twist Bioscience CorporationTWSTHealthcare1.99%n/a400
3NATERA INC (Common Stock) – ticker 45ENTRAHealthcare1.85%n/a610
4Halozyme Therapeutics Inc.HALOHealthcare1.74%n/a660
5Biogen Inc.BIIBHealthcare1.67%n/a390
6United Therapeutics CorporationUTHRHealthcare1.66%n/a780
7Amgen Inc.AMGNHealthcare1.66%2.10%4872
8Spyre Therapeutics, Inc.SYREHealthcare1.65%n/a100
9AbbVie Inc.ABBVHealthcare1.64%2.30%3959
10Exelixis Inc.EXELHealthcare1.63%n/a970
11Iovance Biotherapeutics, Inc.IOVAHealthcare1.62%n/a100
12Gilead Sciences Inc.GILDHealthcare1.57%1.94%4871
13TG Therapeutics, Inc.TGTXHealthcare1.51%n/a570
14Oruka Therapeutics, Inc.ORKAHealthcare1.51%n/a100
15Grail, Inc.GRALHealthcare1.51%n/a400
16Vertex Pharmaceuticals IncorporatedVRTXHealthcare1.46%n/a470
17Regeneron Pharmaceuticals, Inc.REGNHealthcare1.45%0.39%5443
18Alkermes plcALKSHealthcare1.43%n/a400
19Crispr Therapeutics AGCRSPHealthcare1.43%n/a400
20Protagonist Therapeutics Inc.PTGXHealthcare1.40%n/a540
21Neurocrine Biosciences Inc.NBIXHealthcare1.35%n/a820
22PTC Therapeutics, Inc.PTCTHealthcare1.34%n/a650
23BridgeBio Pharma, Inc.BBIOHealthcare1.34%n/a300
24Incyte CorporationINCYIndustrials1.33%n/a430
25Krystal Biotech Inc.KRYSHealthcare1.33%n/a410
1-25 of 159
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Other positions (10)

Part of the fund's official holdings list, but not companies: cash, money market funds, futures and the like.

XBI positions other than stocks
PositionTypeWeight
Contra Metsera IncCash and equivalents0.07%
Ssi US Gov Money Market ClassCash and equivalents0.02%
Contra Akero TherapeutCash and equivalents0.01%
Contra Inhibrx IncCash and equivalents0.01%
Contra Mirati TherapeuCash and equivalents0.01%
Contra Verve TherapeutCash and equivalents0.01%
Contra Blueprint MedicCash and equivalents0.00%
US DollarCash and equivalents0.00%
State Street Global Advisors (Ssga) Is Now State Street Investment Management. Please Click Here For More Information.Cash and equivalents0.00%
Past Performance Is Not A Reliable Indicator Of Future Performance. Investment Return And Principal Value Will Fluctuate, So You May Have A Gain Or Loss When Shares Are Sold. Current Performance May Be Higher Or Lower Than That Quoted. All Results Are Historical And Assume The Reinvestment Of Dividends And Capital Gains. Visit Www.Ssga.Com For Most Recent Month-End Performance.Cash and equivalents0.00%

Concentration

How much of the fund sits in its largest stocks

XBI holdings questions

How many stocks does XBI hold?+

159 stocks as of Oct 28, 2026, plus 10 cash or money-market lines worth 0.13% of assets.

What is XBI's largest holding?+

Moderna, Inc. (MRNA) at 2.27% of the fund. The ten largest positions add up to 17.8%.

Which sectors does XBI invest in most?+

Healthcare (97.3%), Industrials (1.9%), Financials (0.6%).

How often does XBI change its holdings?+

In its last fiscal year the fund's turnover was 71%. Weights move every day with prices, so this list shows the weights on Oct 28, 2026.

More on XBI: Overview · Dividend history

Holdings: the fund's own holdings list, published by State Street Global Advisors, as of Oct 28, 2026. Checked against the fund's SEC Form N-PORT for Jun 30, 2026: 143 of these 159 stocks are in that filing too (the rest changed through trading since, such as the index's yearly rebalance). Quality and Dividend scores and yields: computed by Intrinsiqq from each company's SEC filings and today's price.

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Not financial advice. Analytical data for research only.

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