Spyre Therapeutics, Inc.

SYRE

Spyre Therapeutics, Inc. (NASDAQ: SYRE) is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease ( IBD ) and rheumatic diseases. Spyre's pipeline includes extended half-life antibodies targeting 4 7, TL1A, and IL-23 in development as monotherapies and pair-wise combinati…

Valuation & Multiples

Based on TTM earnings · Diluted shares

Market Cap$8.51B

EPS-$50.71

P/E-1.90

P/FCF-40.75

EV/EBITDA-36.60

FCF Yield–

Div. Yield–

Net Debt/FCF5.5x

Spyre Therapeutics, Inc. intrinsic value

52-Week Range

$22.18$108.92

Profitability & Returns

TTM as of 2026-06 · YoY vs prior year · ROIC = NOPAT / invested capital

Revenue (FY)

$0.00

Net Income (TTM)

-$179M

▲ +25.4% YoY

Op. Margin

–

ROIC

-21.62%

▲ +20.1pp YoY

Cash Flow & Balance Sheet

FCF = operating cash flow + capex · Net debt = total debt − cash · Balance sheet from latest filing

FCF (TTM)

-$209M

▼ -7.5% YoY

Op. Cash Flow (TTM)

-$209M

▼ -7.5% YoY

Net Debt

-$1.15B

Net Cash Position

Cash & Equiv.

$1.15B

Continue Research

Quality Scorecard

Is this a high-quality business?

Dividends

Payout safety and growth

Intrinsic Value

What is it worth?

Financials

Full income, cash flow, balance sheet

Peers

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Held by ETFs

SYRE is in 74 US ETFs. The largest of them, with SYRE's weight in each:

Spyre Therapeutics (SYRE) in three numbers

Quality score: 10/100; Best check: net debt, -$1.15B. Weakest: return on capital, -21.6%.; Quality
Dividend: None; No dividend in the SEC filings we hold.; Dividends
P/E: -1.90; Negative: a loss over the last twelve months. Price to free cash flow -40.75.; Financials

Questions about Spyre Therapeutics

Is Spyre Therapeutics a high-quality business?

Spyre Therapeutics scores 10 out of 100 on Intrinsiqq's quality score, which makes it a lower-quality business on these measures. The score blends 4 checks computed from SEC filings. Its best check is net debt at -$1.15B, and its weakest is return on capital at -21.6%. The Quality tab shows every check against its target.

Does Spyre Therapeutics (SYRE) pay a dividend?

No. Spyre Therapeutics (SYRE) does not pay a dividend, and no dividend payment appears anywhere in the filing history we hold. Nor has its share count fallen meaningfully over the last twelve months, so cash is kept in the business. The Dividends tab shows its cash returns.

Source: 10-Q filed 28 Jul 2026 (period ending 30 Jun 2026), SEC. Price: last close 30 Oct 2026. How this is calculated. Sector medians are approximate S&P 500 benchmarks and update periodically. Analysis, not investment advice.

Spot a number that looks wrong? Check it in SYRE's SEC filings or

Download this analysis as a PDF (Pro)

Data sourced from SEC EDGAR filings and third-party price providers. Scores, valuations, and metrics are algorithmic estimates. This is not investment advice. See our Terms and Methodology.

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