Sionna Therapeutics Inc.

SION

We are a clinical-stage biopharmaceutical company on a mission to revolutionize the current treatment paradigm for cystic fibrosis ( CF ) by developing novel medicines that normalize the function of the cystic fibrosis transmembrane conductance regulator ( CFTR ) protein to deliver clinically meaningful benefit to people with CF. CF is a progressive and life-threatening genetic disease caused b…

Valuation & Multiples

Based on TTM earnings · Diluted shares

Market Cap$169M

EPS-$2.11

P/E-1.77

P/FCF-2.21

EV/EBITDA0.31

FCF Yield–

Div. Yield–

Net Debt/FCF2.7x

Sionna Therapeutics Inc. intrinsic value

52-Week Range

$3.60$8.26

Profitability & Returns

TTM as of 2026-06 · YoY vs prior year · ROIC = NOPAT / invested capital

Revenue

N/A

Net Income (TTM)

-$97M

▼ -22.0% YoY

Op. Margin

–

ROIC

-28.44%

▲ +528.5pp YoY

Cash Flow & Balance Sheet

FCF = operating cash flow + capex · Net debt = total debt − cash · Balance sheet from latest filing

FCF (TTM)

-$76M

▼ -26.2% YoY

Op. Cash Flow (TTM)

-$76M

▼ -25.6% YoY

Net Debt

-$203M

Net Cash Position

Cash & Equiv.

$211M

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Quality Scorecard

Is this a high-quality business?

Dividends

Payout safety and growth

Intrinsic Value

What is it worth?

Financials

Full income, cash flow, balance sheet

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Held by ETFs

SION is in 19 US ETFs. The largest of them, with SION's weight in each:

Sionna Therapeutics (SION) in two numbers

Dividend: None; No dividend in the SEC filings we hold.; Dividends
P/E: -1.77; Negative: a loss over the last twelve months. Price to free cash flow -2.21.; Financials

Questions about Sionna Therapeutics

Does Sionna Therapeutics (SION) pay a dividend?

No. Sionna Therapeutics (SION) does not pay a dividend, and no dividend payment appears anywhere in the filing history we hold. Nor has its share count fallen meaningfully over the last twelve months, so cash is kept in the business. The Dividends tab shows its cash returns.

Source: 10-Q filed 31 Jul 2026 (period ending 30 Jun 2026), SEC. Price: last close 4 Nov 2026. How this is calculated. Sector medians are approximate S&P 500 benchmarks and update periodically. Analysis, not investment advice.

Spot a number that looks wrong? Check it in SION's SEC filings or

Download this analysis as a PDF (Pro)

Data sourced from SEC EDGAR filings and third-party price providers. Scores, valuations, and metrics are algorithmic estimates. This is not investment advice. See our Terms and Methodology.

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