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Taysha Gene Therapies Inc. Quality Score

TSHA

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Quality40

Valuation is the primary weakness (avg 0/100). No single area scores well.

Broad-market heuristics · Not a buy/sell signal

Valuation and growth

Earnings Multiple
0/100
-10.4x

Negative earnings, no valuation support

Cash Flow Multiple
0/100
-10.7x

Negative FCF, no valuation support

Revenue Growth
100/100
21.7%

Above 10% CAGR, strong compounder

Cash Flow Growth
0/100
Negative FCF

FCF negative, burning cash after capex

Business Quality & Capital Allocation

Share Dilution
0/100
739.7%

Heavy dilution above 5%

Margin Trend
100/100
+3700.4pp

Expanded 3+pp, strong improvement

Capital Structure
100/100
-$399M

Net cash position, no leverage concern

2022
$88.0M
$61.0M
2023
$144M
$62.0M
2024
$139M
$64.0M
2025
$320M
$70.0M
TTM
$455M
$57.0M
CashDebt
Return on Capital
0/100
-36.4%

Below 8%, may not cover cost of capital

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Taysha Gene Therapies (TSHA) quality: score, margins and returns

Taysha Gene Therapies (TSHA) scores 40/100 on Intrinsiqq's quality score (a mixed business), a weighted blend of 6 metrics each scored 0 to 100, on -2,792.3% operating margins and -36.4% ROIC. Every metric is computed from SEC filings; this is analysis, not investment advice.

Frequently asked

Is Taysha Gene Therapies (TSHA) a high-quality business?+

Taysha Gene Therapies scores 40 out of 100 on Intrinsiqq's quality score, a weighted blend of 6 metrics each scored 0 to 100, which rates it a mixed business on these measures. Recent figures include a -2,792.3% operating margin and a -36.4% return on invested capital. Quality and price are separate questions: even a great business can be a poor investment if you overpay, so read this score alongside the valuation. The metric-by-metric breakdown is on this scorecard.

What does Taysha Gene Therapies's quality score measure?+

Intrinsiqq's quality score weighs revenue and free-cash-flow growth, operating margins, return on invested capital, change in share count, and balance-sheet strength, each computed from TSHA's SEC filings rather than opinion or sentiment. A higher score means a more durable, capital-efficient business; it is not a buy or sell signal. Open each metric on this page to see exactly where Taysha Gene Therapies scores well and where it falls behind.

What is Taysha Gene Therapies's return on invested capital (ROIC)?+

Taysha Gene Therapies earns about -36.4% on its invested capital, which is weak. ROIC measures how much profit a company generates per dollar put to work; sustained ROIC above its cost of capital is one of the clearest signs of a real competitive moat. Compare it to TSHA's margins and growth on this scorecard to judge durability.

How profitable is Taysha Gene Therapies?+

Taysha Gene Therapies runs an operating margin of about -2,792.3% and a net margin of about -2,728.0%. Revenue has grown at roughly 57.5% a year recently. High, stable margins usually point to pricing power and operating discipline. Margins are most telling next to growth and returns on capital, all of which feed this quality score. This is analysis from SEC filings, not investment advice.

How the market compares: US profitability statistics

SourceQuality score computed from the 10-Q filed 11 Aug 2026, covering the period ending 30 Jun 2026, as reported to the SEC. Data last refreshed 12 Aug 2026. How this is calculated.

Fiscal year ends Dec. Sector medians are approximate S&P 500 benchmarks and update periodically. Checks use broad-market heuristics, so sector norms may differ, and the valuation checks are more cyclical than the quality checks.

Peers

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Held by ETFs

TSHA is in 35 US ETFs. The largest of them, with TSHA's weight in each:

Spot a number that looks wrong? Check it in TSHA's SEC filings or

Download this analysis as a PDF (Pro)

Data sourced from SEC EDGAR filings and third-party price providers. Scores, valuations, and metrics are algorithmic estimates. This is not investment advice. See our Terms and Methodology.

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Not financial advice. Analytical data for research only.

Intrinsiqq is a Netherlands-based company operating in Rotterdam, KvK 73238007.