Amylyx Pharmaceuticals, Inc. Insider Trading

AMLX

Last 12 months

Insiders bought 152K and sold $10.1M on the open market.

14% of the selling was scheduled in advance under 10b5-1 plans. Co-Chief Executive Officer Joshua B Cohen sold $1.88M on Jan 16 outside a plan.

Net open-market

−$9.98M

2 buys · 23 sales

Under a 10b5-1 plan

14%

of the value sold

Insiders who bought / sold

1 / 6

executives and directors

Last open-market buy

May 2026

May 21, 2026

Get an email when AMLX's executives or directors buy, or make a large sale outside a plan.

Trades · last 2 years

Date	Insider	Trade	Shares	Price	Value	Of their stake	Filing
Oct 5	George M Milne Jr Director	Sold10b5-1 plan	30,000	$27.70	831K	3.7%	Form 4
Sep 10	Camille L Bedrosian Chief Medical Officer	SoldNo plan 2 parts	10,028	$32.39 average	325K	3.5%	Form 4
Sep 10	James M Frates Chief Financial Officer	SoldNo plan 2 parts	10,810	$32.36 average	350K	4.2%	Form 4
Sep 10	Gina Mazzariello Chief Legal Officer	SoldNo plan 2 parts	9,536	$32.46 average	310K	4.8%	Form 4
Sep 10	Joshua B Cohen Co-Chief Executive Officer	SoldNo plan 2 parts	30,464	$32.19 average	981K	0.8%	Form 4
Sep 10	Justin B. Klee Co-Chief Executive Officer	SoldNo plan 2 parts	30,464	$32.18 average	980K	0.8%	Form 4
Jul 9 – 10	Gina Mazzariello Chief Legal Officer	Sold10b5-1 plan 2 parts	30,000	$17.97 average	539K	14%	Form 4
May 21	Karen Firestone Director	Bought	3,800	$13.51	51K	6.0%	Form 4
Mar 2	Justin B. Klee Co-Chief Executive Officer	SoldNo plan	29,282	$14.47	424K	0.9%	Form 4
Mar 2	Joshua B Cohen Co-Chief Executive Officer	SoldNo plan	29,282	$14.48	424K	0.9%	Form 4
Mar 2	Camille L Bedrosian Chief Medical Officer	SoldNo plan	6,461	$14.58	94K	3.7%	Form 4
Mar 2	James M Frates Chief Financial Officer	SoldNo plan	7,909	$14.52	115K	4.2%	Form 4
Mar 2	Gina Mazzariello Chief Legal Officer	SoldNo plan	6,844	$14.52	99K	4.8%	Form 4
Feb 23	Gina Mazzariello Chief Legal Officer	SoldNo plan	3,419	$14.14	48K	2.4%	Form 4
Feb 2	James M Frates Chief Financial Officer	SoldNo plan	3,557	$14.65	52K	1.8%	Form 4
Feb 2	Joshua B Cohen Co-Chief Executive Officer	SoldNo plan	15,500	$14.68	228K	0.5%	Form 4
Feb 2	Gina Mazzariello Chief Legal Officer	SoldNo plan	3,448	$14.65	51K	2.3%	Form 4
Feb 2	Justin B. Klee Co-Chief Executive Officer	SoldNo plan	15,500	$14.69	228K	0.5%	Form 4
Jan 15 – 16	Joshua B Cohen Co-Chief Executive Officer	SoldNo plan 2 parts	138,167	$13.59 average	$1.88M	3.9%	Form 4
Jan 15 – 16	Justin B. Klee Co-Chief Executive Officer	SoldNo plan 2 parts	138,188	$13.58 average	$1.88M	3.9%	Form 4
Jan 6	James M Frates Chief Financial Officer	SoldNo plan	3,326	$11.11	37K	1.7%	Form 4
Jan 6	Joshua B Cohen Co-Chief Executive Officer	SoldNo plan	7,715	$11.09	86K	0.2%	Form 4
Jan 6	Justin B. Klee Co-Chief Executive Officer	SoldNo plan	7,715	$11.09	86K	0.2%	Form 4
Dec 23, 2025	Karen Firestone Director	Bought	8,100	$12.45	101K	15%	Form 4
Dec 1, 2025	Camille L Bedrosian Chief Medical Officer	SoldNo plan	6,580	$14.35	94K	3.6%	Form 4
Sep 30, 2025	Justin B. Klee Co-Chief Executive Officer	SoldNo plan 2 parts	29,975	$14.37 average	431K	0.9%	Form 4
Sep 30, 2025	Gina Mazzariello Chief Legal Officer	SoldNo plan	8,828	$14.58	129K	5.6%	Form 4
Sep 30, 2025	James M Frates Chief Financial Officer	SoldNo plan	10,558	$14.65	155K	3.5%	Form 4
Sep 30, 2025	Joshua B Cohen Co-Chief Executive Officer	SoldNo plan 2 parts	29,933	$14.34 average	429K	0.9%	Form 4
Sep 30, 2025	Camille L Bedrosian Chief Medical Officer	SoldNo plan	12,039	$14.58	176K	6.2%	Form 4
Aug 12, 2025 – Aug 13, 2025	Gina Mazzariello Chief Legal Officer	Sold10b5-1 plan 2 parts	30,000	$8.21 average	246K	16%	Form 4
Mar 31, 2025	James M Frates Chief Financial Officer	SoldNo plan	10,896	$3.47	38K	3.4%	Form 4
Mar 31, 2025	Camille L Bedrosian Chief Medical Officer	SoldNo plan	12,425	$3.47	43K	6.0%	Form 4
Mar 31, 2025	Gina Mazzariello Chief Legal Officer	SoldNo plan	9,192	$3.48	32K	4.7%	Form 4
Mar 31, 2025	Joshua B Cohen Co-Chief Executive Officer	SoldNo plan	21,490	$3.47	75K	0.6%	Form 4
Mar 31, 2025	Justin B. Klee Co-Chief Executive Officer	SoldNo plan	21,490	$3.46	74K	0.6%	Form 4
Mar 20, 2025	Bernhardt G Zeiher Director	Bought	10,000	$3.70	37K	New	Form 4
Mar 3, 2025	Justin B. Klee Co-Chief Executive Officer	SoldNo plan	4,595	$3.15	14K	0.1%	Form 4
Mar 3, 2025	Joshua B Cohen Co-Chief Executive Officer	SoldNo plan	4,595	$3.17	15K	0.1%	Form 4
Mar 3, 2025	Gina Mazzariello Chief Legal Officer	SoldNo plan	1,611	$3.12	5K	1.2%	Form 4

Oct 510b5-1 plan
George M Milne Jr
Director · sold 30,000 at $27.70
831K
3.7% of stake
Sep 10No plan
Camille L Bedrosian
Chief Medical Officer · sold 10,028 at avg $32.39
325K
3.5% of stake
Sep 10No plan
James M Frates
Chief Financial Officer · sold 10,810 at avg $32.36
350K
4.2% of stake
Sep 10No plan
Gina Mazzariello
Chief Legal Officer · sold 9,536 at avg $32.46
310K
4.8% of stake
Sep 10No plan
Joshua B Cohen
Co-Chief Executive Officer · sold 30,464 at avg $32.19
981K
0.8% of stake
Sep 10No plan
Justin B. Klee
Co-Chief Executive Officer · sold 30,464 at avg $32.18
980K
0.8% of stake
Jul 9 – 1010b5-1 plan
Gina Mazzariello
Chief Legal Officer · sold 30,000 at avg $17.97
539K
14% of stake
May 21
Karen Firestone
Director · bought 3,800 at $13.51
51K
6.0% of stake
Mar 2No plan
Justin B. Klee
Co-Chief Executive Officer · sold 29,282 at $14.47
424K
0.9% of stake
Mar 2No plan
Joshua B Cohen
Co-Chief Executive Officer · sold 29,282 at $14.48
424K
0.9% of stake
Mar 2No plan
Camille L Bedrosian
Chief Medical Officer · sold 6,461 at $14.58
94K
3.7% of stake
Mar 2No plan
James M Frates
Chief Financial Officer · sold 7,909 at $14.52
115K
4.2% of stake
Mar 2No plan
Gina Mazzariello
Chief Legal Officer · sold 6,844 at $14.52
99K
4.8% of stake
Feb 23No plan
Gina Mazzariello
Chief Legal Officer · sold 3,419 at $14.14
48K
2.4% of stake
Feb 2No plan
James M Frates
Chief Financial Officer · sold 3,557 at $14.65
52K
1.8% of stake
Feb 2No plan
Joshua B Cohen
Co-Chief Executive Officer · sold 15,500 at $14.68
228K
0.5% of stake
Feb 2No plan
Gina Mazzariello
Chief Legal Officer · sold 3,448 at $14.65
51K
2.3% of stake
Feb 2No plan
Justin B. Klee
Co-Chief Executive Officer · sold 15,500 at $14.69
228K
0.5% of stake
Jan 15 – 16No plan
Joshua B Cohen
Co-Chief Executive Officer · sold 138,167 at avg $13.59
$1.88M
3.9% of stake
Jan 15 – 16No plan
Justin B. Klee
Co-Chief Executive Officer · sold 138,188 at avg $13.58
$1.88M
3.9% of stake
Jan 6No plan
James M Frates
Chief Financial Officer · sold 3,326 at $11.11
37K
1.7% of stake
Jan 6No plan
Joshua B Cohen
Co-Chief Executive Officer · sold 7,715 at $11.09
86K
0.2% of stake
Jan 6No plan
Justin B. Klee
Co-Chief Executive Officer · sold 7,715 at $11.09
86K
0.2% of stake
Dec 23, 2025
Karen Firestone
Director · bought 8,100 at $12.45
101K
15% of stake
Dec 1, 2025No plan
Camille L Bedrosian
Chief Medical Officer · sold 6,580 at $14.35
94K
3.6% of stake
Sep 30, 2025No plan
Justin B. Klee
Co-Chief Executive Officer · sold 29,975 at avg $14.37
431K
0.9% of stake
Sep 30, 2025No plan
Gina Mazzariello
Chief Legal Officer · sold 8,828 at $14.58
129K
5.6% of stake
Sep 30, 2025No plan
James M Frates
Chief Financial Officer · sold 10,558 at $14.65
155K
3.5% of stake
Sep 30, 2025No plan
Joshua B Cohen
Co-Chief Executive Officer · sold 29,933 at avg $14.34
429K
0.9% of stake
Sep 30, 2025No plan
Camille L Bedrosian
Chief Medical Officer · sold 12,039 at $14.58
176K
6.2% of stake
Aug 12, 2025 – Aug 13, 202510b5-1 plan
Gina Mazzariello
Chief Legal Officer · sold 30,000 at avg $8.21
246K
16% of stake
Mar 31, 2025No plan
James M Frates
Chief Financial Officer · sold 10,896 at $3.47
38K
3.4% of stake
Mar 31, 2025No plan
Camille L Bedrosian
Chief Medical Officer · sold 12,425 at $3.47
43K
6.0% of stake
Mar 31, 2025No plan
Gina Mazzariello
Chief Legal Officer · sold 9,192 at $3.48
32K
4.7% of stake
Mar 31, 2025No plan
Joshua B Cohen
Co-Chief Executive Officer · sold 21,490 at $3.47
75K
0.6% of stake
Mar 31, 2025No plan
Justin B. Klee
Co-Chief Executive Officer · sold 21,490 at $3.46
74K
0.6% of stake
Mar 20, 2025
Bernhardt G Zeiher
Director · bought 10,000 at $3.70
37K
New position
Mar 3, 2025No plan
Justin B. Klee
Co-Chief Executive Officer · sold 4,595 at $3.15
14K
0.1% of stake
Mar 3, 2025No plan
Joshua B Cohen
Co-Chief Executive Officer · sold 4,595 at $3.17
15K
0.1% of stake
Mar 3, 2025No plan
Gina Mazzariello
Chief Legal Officer · sold 1,611 at $3.12
5K
1.2% of stake

How to read this. Insiders sell for many reasons: taxes, diversifying, a house. Open-market buys are rarer and say more. A 10b5-1 plan is a trading schedule set up months in advance, so those sales were not timed on news. Large holders (funds and 10% owners) are listed under Everything but not counted as insiders. If you own or watch AMLX, we send a push when an executive buys or makes a large sale outside a plan.

Source: SEC Form 4 filings, filed within two business days of each trade and checked for new ones every hour.

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Held by ETFs

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Data sourced from SEC EDGAR filings and third-party price providers. Scores, valuations, and metrics are algorithmic estimates. This is not investment advice. See our Terms and Methodology.

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